Carmina Burana

A work that many have, at least heard a piece, of is Carmina Burana. Carl Orff composed this piece of music in 1936. A German, he was one of few composers that continued work during the Anti-Semitic rule of the country. Orff based his work off of a collection of poems found at the monastery of Benedikbeuren that dates back to the Twelfth Century! Carmina Burana is a set of twenty-five pieces that concern many of things going in everyone’s life today.Drinking, gambling, love, sex, fate, and fortune are just a few of the topics Orff composed of. 1 In this concert report I will go through the pieces that stood out the most to me. As mentioned, the most famous piece of this work is the opening sequence, â€Å"O Fortuna†. This glamorous piece begins with the full orchestra and chorus playing a loud, brave tone that quickly drops off into, what I hear as a loud whisper, sung by the entire chorus. Orff doesn’t let the listener take a break by coming back with same loud tone that the piece began with.Percussion instruments can be vividly heard throughout this opening piece, seemingly above the rest of the instruments. Early in this work, Orff establishes his theme of a â€Å"Wheel of Fortune†. 2 With the boldness of the opening sounds I feel that Orff is setting the tone for the whole work. Although the work is sung entirely in Latin, the translation of the first movement may surprise most people. The opening words â€Å"O Fortune† gives the listener an idea what the piece is about. As the piece goes, Orff describes fortune as oppressing and poor, in what I believe he was feeling at the time.The last words of this movement, in translation â€Å" everyone weep with me â€Å" were the biggest surprise to me because the orchestra ends the piece in carnival like melody. The second movement of Orff’s work is titled â€Å"Fortune plango vulneraâ€Å". This is personally my favorite piece of the work because of the hit or miss har mony. Different instruments take turns using the high-low rhythms, along with the chorus. The male voice is prominent at the beginning but soon after you can hear the voice of the full orchestra. Before reading the text n translation, this piece gave the idea of a rabbit jumping through to pasture or meadow to a novice listener like myself. This piece picks up from the last movement still pertaining to fortune. In the latter part of this piece Orff actually wrote in his overall theme by mentioning â€Å"the wheel of Fortune turns†. The fourth movement, â€Å"Omnia sol temperat† is sung in a completely different way. It begins with a male soloist singing, accompanied softly by violins. The way Orff chose to display this movement shows that there is no defined rhythm he is following.The soloist singing in a profound masculine voice sets the tone for this movement. The next movement discussed stands out as being one of the longest works of the cantata. â€Å"In taberna q uando sumus† opens with stringed instruments followed by percussion, and then a variety of other instruments join with the chorus. â€Å"When we are in the tavern†, the title sets this piece up for what I think would have a been a popular movement when it originated. Orff tells of drinking and gambling at the tavern, then goes on to list thirty names such as â€Å"the rich man† and â€Å"the poor man† that all drink.This stood out to me because I didn’t see this coming at all! It is also my least my favorite piece of the work. With the setting what it is, I didn’t particularly like the minor tone heard on and off in this movement. Orff could have been trying to relay a message by this of the tavern as a sometimes dark, bad place. The last movement of the cantata, â€Å"O Fortuna† begins just as the piece began with the same instruments and harmony. The last movement mirrors the first in a way that makes the listener understand the true tone of this work.I compliment Orff for doing this because I feel it is necessary. With a piece as strong and bold as this, I would think most composers would have chose to do this. After going back and re-listening to the first and last piece, there is no difference to my ear. The last movement does not lack any of the strength of the first movement; it’s a repeat that is well deserved. This theme has been used in many American movies, but sadly it is seldom recognized. Carl Orff made his mark in music history with Carmina Burana, namely the first and last movements â€Å"O Fortuna†.There are many more movements in this piece that all have uniqueness and glamour. Even though I am not the most avid Carl Orff fan, this piece surprised me with every movement. The overall performance of this piece was outstanding, with all the different melodies and tones, the use of full orchestra to solo vocalist, and an excellent job of conducting by Jeffery Thomas, I can see how this piece gained as much fame as it did. 1 â€Å" The Enjoyment of Music† Eleventh Edition, Kristine Forney and Joseph Machlis 2 http://classicalmusic. about. com/od/20thcenturymusic/a/carmina_burana. htm

Elisabeth Bishop’s poem “The Fish” Essay

Elizabeth Bishop’s poem The Fish narrates the changing attitude of the speaker towards the fish. First, the fish is described as ancient and grizzled, showing signs of death and decay. However, upon closer inspection, the fish is made out to be a survivor of many battles. Through the use of figurative language, the poet shows the speaker’s shift from noting only the fish’s dejection to admiring him for his past glories. Bishop begins with the personification of the fish into a figure of defeat and age. The speaker mentions that the fish had not fought at all, as though he had given up all hope. She compares the fish’s skin to old wallpaper which would not be securely attached to the wall as skin loses firmness with age. In addition, Bishop details the extent of the fish’s injuries, everything from lice and barnacles to the fresh blood of his wounds. Such imagery invokes feelings of decay and abandonment as parasites are allowed to slowly consume him. The speaker also contemplates the fish’s innards, suggesting that his has become a mass of flesh and bone without spirit. The speaker furthers the personification of the fish by looking into his eyes and remarking that he had not looked back fully. Instead, the fish had only shifted his stare a little towards the light, further suggesting lack of will while giving the fish a very human feeling of dejection. Not caring about the face of his conqueror, the fish only seeks to confront death, represented by the light that he turns towards. The focus on the fish’s physical structure denotes the fish’s lack of spirit yet it is this very lifelessness that gives the fish the human emotions of apathy and hopelessness. Through the personification of the fish, the poet shows the speaker’s projection of lack of spirit and hope onto the fish. In contrast, the speaker’s discovery of past hooks imbedded into the fish’s mouth gives him the persona of a fallen war hero who has survived many battles in the past. The speaker’s perception then changes from one of lifelessness to one of courage and animation, denoted by the admiration in the speaker’s tone. Upon seeing the frayed lines, she uses verbs of action and struggle as she imagines the fish fighting and breaking the line. Thus,  the poet’s comparison of the lines to ribbons furthers the fish’s appearance as a hero retaining the medals of his victory. The further comparison of the thread to a beard of wisdom shows the speaker’s admiration of the fish’s accumulation of experience through time. The author then explains that he boat become filled with victory in the appearance of a rainbow. A rainbow can be associated with triumph and survival, as the viewer can enjoy the calmness after a storm, often a scene of chaos and potential violence especially combined with the boat setting. Through viewing the remains of the past struggles that the fish has faced, the speaker’s perception of the fish changes him from a being in decline to the survival of past battles. In The Fish, Bishop transforms an old fish the speaker caught into a glorious figure of reverence. Bishop uses personification and analogies to set up the fish as dejected and lacking in spirit. However, the speaker’s perception changes and tone is markedly more of admiration while symbolism is added as the remains of the fish’s struggle become the trophies of victory. By employing personification and symbolism, Bishop uses figurative language to denote the speaker’s changing understanding of the fish.

Green Day

Green Day is one of the most influential pop punk bands. The band was formed in 1986. They have sold more than 85 million records worldwide.They won many awards and was inducted into the Hall of Fame in 2015. Early Years Billie Joe Armstrong, the lead singer was born on February 17,1972. He was born around a musical atmosphere since his father was a jazz drummer and his mother loved music. Because of his parents, Billie and his siblings were encouraged to play musical instruments.Michael Ryan Pritchard also known as Mike Dirnt was born on May 4, 1972. He was put up for adoption because of his mother's addiction to heroin. Billie and Mike met in middle school. They formed their own band with John Kiffmeyer in 1986. The band was called the Sweet Children. They were 14 year olds at the time. Band Members Billie Joe Armstrong, Mike Dirnt, and John Kiffmeyer were the original members of the band. John Kiffmeyer soon left in 1990 to attend college and was replaced by Tre Cool. Billie Armstrong, Mike Dirnt, and Tre Cool are still in the band to this day. Past members were Raj Punjabi, Sean Hughes,Aaron Cometbus, and Dave Henwood. Billie Joe dropped out of high school to devote his entire life for the band. Tre Cool also dropped out of highschool when he was a sophomore and dropped out of community college also. However, Mike Dirnt pushed himself to complete his education. Mike Graduated high school and completed more than one year at community college.Breakthrough Success After their breakout album, Kerplunk record labels were interested in the band. They left Lookout! to get signed at Reprise Records. After getting signed, they worked on their album, Dookie. The album became a big success. Their songs â€Å"Longview†,†Basket Case†,and â€Å"When I Come Around† from Dookie were continuously played on MTV. They sold 10 million albums with Dookie. They were nominated for many awards such as American Music Awards and Grammys.Career Green Day first started playing at DIY 924 Gilman Street club in California. They earned some fame at the club and eventually got signed at Lookout! Records. From there, they released Kerplunk and they got big success after. They decided to leave Lookout! to get signed to Reprise Records. After getting signed, they started record Dookie. Like most of their albums, the album was recorded in a few weeks. Dookie was also a big hit but Green Day started to be criticized by other punk fans. They were put on a list of people who were never allowed to play again at DIY Gilman Street. Their albums after Dookie, Insomniac and Nimrod were good but the band was losing some fame. They released Warning and was criticized by critics because they took a different turn in their music but they weren't ready for American Idiot. American Idiot was a huge hit and they continued to make music. Rock and Roll Hall of Fame After 29 years of playing music together in the band, Green Day was inducted into the hall of fame. They were inducted in the first year they were eligible. On April 18,2015 in Cleveland, Ohio,Fall Out Boy inducted them into the hall of fame. They talked about how Green Day changed them and how they wouldn't be a band without them. Then, Billie Joe thanked his band,friends,family and fans for helping him get through everything. Before the induction they played 2 surprise shows in Cleveland.

Electronic Medical records Assignment Example | Topics and Well Written Essays - 1250 words

Electronic Medical records - Assignment Example The present study would focus on the electronic medical records are computerized records. They are introduced in the medical world to replace the tedious paper based records. Paper based mode of recording is the most used by many hospitals. Most medical practitioners find it cheap and easy to use this method. Regardless of the cost, paper based records, require a lot of storage space unlike computerized records that only take the space of a hard disk or any other storage device. Electronic media records can be easily located in case of reference according to HIMSS. This is quite not the case with paper-based records where a lot of room is required to store up the paper work. Trying to locate paper-based records is time consuming and at times results to inaccurate information or lack of it generally. Electronic Media Records are known to be cost effective, thus improving the quality of service, cost and general wellbeing of the patients in the long run. This eventually leads to a redu ction in the cost of hospitalization for patients and improves the overall safety of the patient. Betsy Johnson Regional Hospital’s aim behind the institution of the EMR was to improve efficiency in record keeping, operations and patient care. The successful implementation of a project depends largely on its planning and efficiency of the project team as noted by HIMSS. According to the General Manager of the hospital, it was important for the hospital to roll out a planning development strategy on the implementation of the Electronic Media Records. ... Resources for and Constraints to the Implementation of the EMR System Estimating the cost of a project is important if the same has to be successfully implemented according to Whitehead (2003). This was the greatest determinant as to whether the EMR system would be successfully implemented. The hospital organized its board members and come up with a reliable source of funds for the implementation of the EMR. Fortunately, the hospital had most of the required resources in terms of funds, skilled personnel, Internet connectivity, and a well networked set of computers. The main constraint was that the hospital needed better firewall software considering the need to protect personal and confidential records from illegal intrusion and hacking. The hospital also needed an effective EMR software. It was noted that for the effective functioning of the system, a more powerful server would be needed together with more powerful network devices. One main issue that relates to the application of the EMS in hospitals is privacy. Indeed the issue of patient privacy is as weight an issue as patient autonomy. Considering that the EMS makes part of patients’ records accessible to over 500,000 payers, care providers, insurance firms and other organizations, the project team working with the hospital’s management had to establish a privacy policy to be applied by the hospital in handling patient records. This would ensure that chances of privacy infringement were as much as possible minimized. Impact of the Technology According to the general manager of the hospital, the institution would expect a lower mortality rate due to cut down on medication errors with the implementation of the electronic media records system. The hospital also expected to save close to one

Managerial decisions Term Paper Example | Topics and Well Written Essays - 2250 words

Managerial decisions - Term Paper Example More revenue will be generated at a lower cost of production, which is an additional advantage to the company. Contract workers are paid less money than full time employees, and this will be a great advantage to the company as a whole. Introduction According to Kotler & Armstrong (2004), the elements of supply and demand in business are interrelated, and in some cases, they also affect the price of a certain market offering. However, in this case it is assumed that the price is constant and the aim is to establish how supply can be increased in order to meet the rising demand of certain goods without offsetting the prevailing market trends. Economically, if the demand for a certain product increases, then its supply also increases. This relationship will be illustrated using a supply curve later in the paper. Therefore, this paper seeks to explain in detail the relationship between supply and demand in detail and show how this can affect managerial decisions. In some cases, managers need to make decisions that do not affect the viability of the organization in the long run, trying to meet the rising demand for a certain product. ... products offered in the market remains the same, but this issue of the rising demand has to be addressed in order to cater for the needs of customers, who are valuable to the organization. It is also assumed that this increase in demand may not be permanent, and hence the need to put effective measures that do not impact negatively on the operations of the organization. Therefore, the main question to be answered in this case is: Should our company hire temporary or hire new workers to handle the increase in demand for our products? Essentially, there is a need to maintain production costs at a lower level while increasing the supply of the product offered by the company. This is meant to ensure that the company remains viable and that it is also able to operate profitably since the price is not going to change in this particular case. The only thing that will change is the supply of the products offered. An increase in supply entails that more sales are likely to be generated. This also means that more revenue will be realized from the operations of the organization. As such, a holistic approach has to be taken in order to make sure that the workers who are going to be hired will not greatly increase the operational costs, which may impact the viability of the organization. Factors or costs There are various costs that need to be taken into consideration when making managerial decisions that have economic implications on the operations of the organization. Hiring temporary workers impliedly means that the company will not incur a lot of labour costs because of the following reasons: The organization has the autonomy to determine the wage rate of the contract workers. The company does not have the burden of paying fixed salaries to these workers since this may increase

Human Resources - Attraction and recruitment Case Study

Human Resources - Attraction and recruitment - Case Study Example One of the ideal attraction strategies is to use their online presence to get the attention of potential workers. Websites not only provide businesses with worldwide exposure, they also are convenient platforms for target individuals to access the business. In the case of Pearson Publication, a website will enable potential workers get access to the kind of services offered by the company to its customers. They will be able to gauge the level of skills needed as well as what is expected of workers in the organization. The online strategy to attract more workers is ideal for the fact that it is able to attract people from all walks of life (Nankervis, Compton and Morrissey, 2009). The company will therefore be able to have a wide range of work pool, representing people from different backgrounds, and who can reach out to the diverse customer base that the company serves. Another way through which Pearson Publications can attract high level workers is by carrying out open house sessions in the areas where its services are (Hor, Keats and Holmes, 2008). These open house sessions can be carried out in university and high school career days or during any other sessions that are designed to get the public to know more about different organizations. These sessions are quite effective in helping potential employees gain first hand information about the company and the kind of professionalism it expects from its employees. Recruiters attending these sessions are also able to gauge the expertise of potential employees before they actually employ them. One disadvantage of this kind strategy is the fact tat it only reaches a limited number of people (Nankervis, Compton and Morrissey, 2009). Through these open house sessions, Pearson Publications can get any employees they need to help them achieve their objectives in a certain business area. Target

Discuss the factors that contributed to the birth of the renaissance Essay

Discuss the factors that contributed to the birth of the renaissance in italy - Essay Example Additionally, the renaissance was a period when people rediscovered learning by changing their attitudes about themselves and their surroundings, and it was an exciting time of new inventions, and great discoveries, magnificent buildings, and beautiful art (Yeland). Renaissance goes forth from Italy because many of the forces that were slowly but radically transforming the medieval thinking into modern thinking were more active than in other places in the world; this paper will dwell on exploring factors that contributed to the birth of renaissance in Italy. One of the factors that largely contributed to the birth of renaissance in Italy was Italy’s geographical location (â€Å"The Italian Renaissance†), which strategically placed the country in contact with the Byzantines and Arabs who had long preserved classical knowledge and culture, thus, putting it in a better position to absorb the Greek and Roman heritage. In that case, Geography gave Italy an advantage over Nor thern Europe because it enabled the country to amass wealth and build capacity to break off from the feudal system because, stretching into the Mediterranean sea and strategically situated at the heart of Europe and the Byzantine empire, Italian cities took part in international trade and market economy. In this regard, Italy came in contact not only with the massive flow goods, but to also with the extensive flow of ideas much earlier than other places in the world, thus, flourishing both economically and intellectually. A second causal factor attributable to renaissance was the new secular hunger for discovering texts, which had long been ignored that arose in Italy in the 14th century; secular readers developed an appetite for seeking out, reading and spreading old works, majorly classical writings, on a large scale, thus, new libraries sprung to facilitate access to books. Many significant writings of the classical works found their way back into Europe both by merchants who exp loited the new interest in older texts and by the incoming scholars who had been invited to teach in Italy. The fall of Constantinople was also a reason that saw the influx of many Greek scholars with their precious manuscripts into Italy, which inevitably led to the pervasive dissemination of the Greek classical texts all over Europe thus sparking off the renaissance subsequently. The birth of the printing press also sparked the Italian renaissance because it made it possible for the almost forgotten old classical texts to be mass produced, thus reaching large audiences at the same time, allowing renaissance to develop in return. Additionally, the political context in Italy, which was characterized by the need for display and administration, can be attributable to the onset of renaissance because the massive changes in styles of art including the outlook of artists required support of the wealthy patrons (Wilde). Artists were keen to explore their renaissance ideas were well suppor ted to produce masterpieces by the new rulers of the Italian cities who sought to assert themselves through conspicuous display with ostentation, including all forms of art and creativity. Nevertheless, development of humanism, a new form of thinking and

Globalization and Media Essay Example | Topics and Well Written Essays - 2750 words

Globalization and Media - Essay Example The influence brought about by globalization in the music industry underscores the intercultural influence, the problems on piracy, and impact on locally produced music around the world. Hollywood as Center of Globalized Music A place in the United States called Hollywood is almost entirely synonymous to talent, fame, and glamour. This is still true if looking at the history of the birthplace of global music. Hollywood in 1915 spells out the â€Å"professional [and] polished recorded entertainment† (Williams 1). Ever since, Hollywood is a center of musical dream and fame. Nowadays, its capacity to reach the global audience is an advantage to influence their message, trend, and philosophy. The dawning of modern technology has increased this capacity, that in a span of minutes, the audience from the other side of the globe would be able to listen to a new song performance. This speedy access of American music has threatened the locally produced music from other countries. Althou gh foreign artists can enter into the Hollywood realm, their percentage is discriminate and cannot prove an exchange of culture in music. More so, the musical performance of these foreign artists is of American standard and influence. In this note, the so called ‘globalization of music’ becomes questionable. ... However, even if in the presence of such agreement, the local music industry still fears to be eaten up by dominant countries. Figure 1 of Appendix A shows the status of international music with respect to its country between the years 2003-2007. It clearly shows that the American music, dominates the rest of the local music industries in the international market. Its nearest contender according to statistics, United Kingdom, is shown to be too distant to be actually called a competitor. As stated earlier, the ability of the American artists to have a larger share of audience stemmed from Hollywood’s extensive market share. Multimedia has helped the success of the American music into the international scene. Figure 2 of Appendix A shows the latest report of the International Federation of Phonographic Industry (IFPI) on the top selling songs last 2010. Noticeably, all of the said songs and albums were produced in the United States which serves as a proof that American songs do minate the international airwaves. The songs on the list all made international success and made the country as â€Å"the largest digital music market in the world† (IFPI, 12). Since the radio is not the only means of distributing music and the internet is readily available for anyone to use, the influence brought about by the internationalization of music has become phenomenal. Such influence and fast access of music helped raise global awareness through charity-run music; however the downside of modern music videos spread throughout the continents. Globalized Music and Its Influence Sparks rise from the glamour of what has been called â€Å"models† of influence in the media. Through music, one can express message and sentiments that could trigger more

Digital Marketing Bagel Nash report Essay Example | Topics and Well Written Essays - 3250 words

Digital Marketing Bagel Nash report - Essay Example Their bakery range provides bagel bars and bagel to both food service as well as retail customers (Bagelnash, n.d.). Bagel Nash is the highest search term on Google. There is limited digital presence as the digital communication is done through the company website only and it does not invest a lot of money or time in digital marketing. However, it has its existence on Facebook , Instagram as well as on twitter but does not have its own app. A complete analysis on the digital presence and strategy of this company will be discussed later in this report. The main purpose of this report is to provide a marketing strategy to achieve the planned digital objectives to benefit Bagel Nash in the field of improving their existing digital presence. A comprehensive micro as well as macro analysis is conducted. The report also encompasses implementation plan to give details of the activities and when those activities are to be executed. The key findings of content analysis are: Focus is on the internal and external factors which have affected the Bagel Nash; they should also pay attention on the human resources for successful packaging and service; a test was conducted in order to witness the experience of customers when they are trying to collect the information from the Bagel Nash website; total number of visits made on each device and on every mobile gadget within the last month has been shown. It indicates that desktop version has received the maximum number of new users as compared to the mobile and tablets. Moreover, it was also found that maximum number of new users is generated from Apple iPhone to view the Bagel Nash website. The facebook page report shows that the target customers are mostly youngsters but it was also noticed that the people of middle age group are also enjoying the fast food offered by Bagel Nash. The main aim of competitor scrutiny is to present a complete

Indicate a person who has had a significant influence on you, and Essay - 1

Indicate a person who has had a significant influence on you, and describe that influence - (and one extra option) - Essay Example To me, scientists are the people who really make a difference in the world. Their effort gives rise to products that the whole world makes use of and benefits from. Even if a scientist does not manage to develop a product in his life time, he leaves sufficient information for others so that they may follow him in the same footsteps and ultimately reach the goal that the deceased ever dreamt of. Benjamin W. Lee who has been a great Korean-American physicist is a source of influence for me. Coincidently, he was related to me. He died away a couple of years ago. In the period that urgently preceded his death, he had been working upon renormalization theory. Unfortunately, he could not achieve the goal he wanted to as his life ended before he could do that. Being related to him and accoutered with good scientific comprehension skills, I felt it as my responsibility to take my uncle’s mission further and complete the rest of his work. So I took it as a task. Benjamin was both my friend and tutor in scientific discussions. If there is one way I can show my respect towards him, that is by accomplishing his mission. If I am a physicist today, Benjamin W. Lee is the most dominant reason for that. He was a physical model and realization of my dream personality. I always wanted to be like him. Many of my cousins and brothers used to talk to him generally. I remember that my discussions with Benjamin were always science oriented. I knew how he started over with the renormalization theory, and what steps he had taken in its way thus far. Although I saw it as my duty to carry forward his work, I was not mature enough to do that by the time he died as I was studying. I had to build my academic career first. So I resolved to take higher education in America in Elementary Particle Physics. Since my childhood, I always found interest in Nuclear Physics. It was fundamentally because of Benjamin, that I decided to take Elementary Particle Physics as my major subject given

SQL Server Column Level Encryption Case Study Example | Topics and Well Written Essays - 500 words

SQL Server Column Level Encryption - Case Study Example Even though firms try to encrypt data with various methods and keys, it has been noted that these companies are exposed to two major categories of threats (Jayanty, 2011). Chiefly, restricting access to sensitive information is a basic protective approach to the firm’s data. However, considering that cyber-attacks comprise a major threat to business and research firms, it is observed that access restriction is not enough. Consequently, encrypted data and restricted access to sensitive information suffer from the possible virus attack that can destroy the data rather than expose it. With this in mind, ABC Institute of Research and XYZ Inc. are vulnerable to losing data or having their research finding on genetics expose to their rivals. For this reason, column-level encryption using symmetric keys (Aqarwal, 2011). Under the circumstances defined above, when encrypting data, it is important to note that data can be accessed in two ways. Firstly, sensitive data is stored in forms of memory and anyone can have access to these memory devices. Secondly, sensitive data can be acquired from its storage device for access to another device. As a result, data encryption should ensure that once an unauthorized personnel is able to get to the data, access to that data is not discernable using a simple query. Ordinarily, ABC and XYZ would store their research findings in various columns that comprise of genetic patterns, associations, links, and procedures of deciphering various DNA codes that all need to be encrypted. Using the SQL Server Symmetric key encryption, the SQL Server allows the encryption hierarchy that needs to be followed to the latter. Forthwith, the hierarchy allows the creation of a master key for the SQL Server which provides the first step of encrypting the database using a password.  

Hul and Nirma Company Full Year of Comparison Essay Example for Free

Hul and Nirma Company Full Year of Comparison Essay The success of Nirmas umbrella branding strategy has led to a change in the competitions marketing strategies, as well. Many of Nirmas competitors are now consolidating their brand portfolio and consequently gaining more bang for their advertising rupee. In a changing market environment, the company has relaunched Nirma Yellow Washing Powder and Nirma Beauty Soap, two of its strongest brands. Nirma Yellow Powder is being re-launched with improved formulation and new advertising. This is an extension of the original ad which will return after the launch is over. Nirma Beauty Soap is being re-launched with a new shape, fragrance and a smarter, brighter pack to improve shelf visibility. Promotion Nirmas success is synonymous with its advertising and marketing strategy. When Karsanbhai Patel started selling his detergent powder, he decided to call it Nirma, derived from the name of his daughter Nirupama. In the early years, the Nirma packet featured a lady washing a garment. Later, however, the design was changed and an image of his daughter was featured on the pack. The white dancing girl, featured in Nirmas television advertising, is perhaps the most enduring image of Nirma. Though Ms. Patel passed away in a car accident, she continues to live on in the corporate logo and the best selling brands of the company. Nirmas advertising has always focused on the value-for-money angle. Its simple and catchy jingle Dudh si safedi Nirma se aye, rangin kapda bhi khil khil jaye has continued to echo in the drawing rooms of middle-class Indian homes through the decades. While the jingle stresses on the product, it also salutes the savvy and budget-conscious Indian housewife. The jingle, which was first aired on radio in 1975, was broadcast on television in 1982. It is one of the longest running jingles and the spot has seen very few changes since the time it was first aired. For the re-launch of Nirma, the company has developed new spots but they are variations of the old favourite. Once the re-launch is complete, the company plans to go back to the original advertisement. Nirmas promotion strategy, too, has many firsts to its credit. The company pioneered product sponsorship through the electronic media. Besides, the company has developed a unique advertising strategy new products are launched with no advertising support. Once the distribution glitches are sorted out and the product reaches the shelves of retailers, the company begins to advertise it. The umbrella branding strategy helps to give new products instant recall without increasing the advertising expense.

Globalisation and the Global City

Globalisation and the Global City Introduction Globalization, it is not a new phenomenon (Stead, 2012) but has massive influenced in the late 20th century around the world, which has strongly affected on urban system in Europe, economics, political, cultural, environmental dimensions. People speculate and make hypothesis about globalization is related to competitiveness of cities with strong economic, innovative and creative ideas or structure on city planning. Most of researches about competitive city are premised on cities do compete to each other, however, few scholars do question about it. What is competitiveness? Is it comparison with others? What aim do they want to achieve? Definition of competitiveness The definition of competitiveness is different in several aspects. For companies, it is ability to produce products and service to meet the needs of customers and make maximum profit. For nations, it is degree to extend peoples income and maintain harmony of country with specific conditions within the world (OECD, 1994). For cities, it is an ability to generate better life, better goods, and better investment (Oyelaran-Oyenika, 2013). Competition is everywhere, but to what extent can be defined as competition between cities. It is hard to clearly contend and identify do cities or regions compete, in terms of different dimensions of definition in competition, and different contentions. The competition is between nations- states or cities and regions? It is hard to clarify which one is it, can the competition between cities be the one within states? London as a city usually presents as United Kingdom in global ranking. Such as in wealth of country ranking, technically, most of GDP are from London, which literally can present United Kingdom. This paper is to discover whether cities or regions compete to each other or not, and what do they compete for. Generally, there are two different criteria: economics aspect, and innovation or creativity. To question is global city can present competitive city? Some emerging challenges from globalization, technology changes, new economy, demographic density, and uncertainty for cities and regions. Cities compete? Very few studies have showed cities dont compete. Krugman (1995) contends that cities and regions do not compete to each other, they are fields for companies to compete for innovative and creative people and market.ÂÂ   Nevertheless, Porter (2016), has argued that cities compete to each other. Cities compete in different ways from state-nations, they dont compete to win trading or assert the territory, which nations-states do. Moreover, it is not like business competition, cities competition doesnt concentrate on any single object to make the maximum profit. They do compete funds from government, tourism, population of the city, wealth, employment, investment and good reputation across the country or within the world (Begg, 1999; Saez, 2015; Favero, 2016; Ratcliffe, 2006; Stewart, 1996). The prevailing urban policies are concentrated on social circumstances, affordable housing, for example, these are important for cities competitiveness (Porter, 1994). Such as, in UK, there was a competition for cities and towns, to elect the best city or town through notable feature, significantly regionally/nationally, historical features and forward looking attitude (UK gov., 2001). The title from the competition may lead lots of effects for the city. Competitiveness of city is deemed performance of city occasionally, and it can present quality of life (Begg, 1999; Rogerson, 1999). Production of city is dynamic measurement for citys competitiveness. The main key indicators of competitiveness: economics, technological innovation, environment, global linkages, government management, and social cohesion (Ni, 2013). However, most of researches intensify on economics. In Faveros (2016) paper, he referred that hard economics, such as, cost of labour and employment rate of city are the most common hard economics factors to be discussed in citys competitiveness. When employment rate is higher than others may mean that the city is more competitive. On the contrary, open urban climate may influence competitiveness and is more like soft economics in urban development. Porter (1998) has stated that environment does affect cities competitiveness, economic extension or development may be solution for city growth. In the past, cities could compe te for goods and services, due to the fast- changing environment, contemporary, people is crucial element. Florida (2002) has built 3Ts model, which includes technology, talent and tolerance, these three factors attract creative people flow into cities and lead citys growth. Additionally, Crossa (2016) has asserted that creative city is capable to attract all kinds of professional people turns to be more competitive in this world at present. Cities which are more diverse and innovative may lead inflow of population. Innovative and creative people are fundamental to cities and regions; they are implements to interest firms and investment, lead success and economics growth for the areas (Paas, 2012). However, major competition in cities and regions is unclear or be demonstrated, there are multi- objectives in different areas to compete for, conversely, firms have clear single objective in competition- profits (Porter, 2016). Consequence from competition. Globalization is one of trends in governments, cities are facing some challenges about financial pressure, national security, institutional relations and role of government changing, environmental degradation, cultural and social changing, and lead to borderless, increasing competition and cooperation within cities and regions (Ratcliffe, 2006). Cities can borrow successful ideas and practices from other cities through globalization (Stead, 2012). It may bring legislative and administrative changes of localized institutions and policies, and raise competitiveness in cities and regions. However, while competition is happening, cooperation is acting simultaneously, such as, INTERREG Programme; it is facilitated cooperation by the EU with planners around Europe for their common development. In addition, cooperation between cities and regions can developed by making sister cities to build networking and promote cultural notions. Brakman (2015) claims that cooperation by having twinning c ities can decrease transaction cost and significantly grow faster, which facilitate cities more competitive. Tosic (2007) also asserts that cooperation may lead stronger competitiveness and strategies of planning. Continuing from INTERREG Programme in Europe aids countries, cities, counties, or regions to address problems and derive experiences and apply new approaches from others, also cope with variety of things from different fields. B-Team, it is one of projects from INTERREG Programme which is about development of brownfield before greenfield land as a principle of continuous growth in Belfast, it was involved 14 partners from 11 different countries ran for three years to regenerate brownfield to be more efficient for communities and aimed to help partners to improve regeneration policies and developed integration of planning process. This project illustrates transferability by publishing to share with others who are interesting in it and may adopt it (B-Team, 2012). Significan tly, it has great influence on investment. The participatory urban planning is a method to attract investors, stakeholders and actors to charm their interest and find out innovative solutions and procedures. Cooperation in this project do affect in regeneration process, and learn wider range of implements and manners, additionally, raising competitive in the city. Once city is more competitive, it possesses advantageous position in competitions. Competition between cities and regions has successfully attracted government and investors with forcing local institutions and governance to develop and reform (Lever, 1999). Competitive city generates economic growth and wealth with extending local market, creating opportunities and jobs for commonality, allocating more funds for infrastructures and planning (Oyelaran-Oyenika, 2013). Being competitive attracts creative and innovative individuals and corporations gather. For example, in China, economic boom has been leading strongly influence on construction, which causes more competition between cities. Beijing and Shanghai, two colossal cities were competing the opera houses, which was designed by famous French architect. Contemporary, these constructions have successfully attracted attentions, also brought enormous influence for city (Wyne, 2006). It may lead tourism growth, and economic growth indirectly. The competition can arouse faithfulness and pride of residents and people m ay understand local authorities agenda better. Gospodini (2002) contends there are two parts of cities, which are opposite extremes in European urban system, metropolitan cities and smaller peripheral cities without indigenous resources for development. Rural regions may be more active to competition than urban regions, and try to stand out from it to get more opportunities for region and be more competitive to increase attention in certain competition. However, competition has driven by localized government and institutions, which may lead different results. The Three Sisters competition which is running within Southern Ireland- Waterford, Kilkenny and Wexford, competing the title of European Capital of Culture 2020. The title may bring tourism growth for the county, which lead economic growth in rural and urban area of Ireland. The competition is taking place in 2015 and 2016, which is a long-term form of planning, the result will be released in 2020. For years competing to each other, leading higher reputation and more well kn own, this title may bring growth of tourism and investment, having impact on economic growth. The reputation of the city would boom in the world, especially in Europe. City would have more funds from national government, retrieve local authorities with economic growth. In order to win the competition, local government may propose some policies for locuss development. There may be some special constructions or operations to stress on their characteristics, renewing heritages, or re-planning the place. However, there are some issues in rural area, three counties have limited fiscal resources and innovative ideas, which may cause passive operations on promoting. In Waterford city, for example, promotion flags of the competition are hung in city centre, but realistic situation is that few people have heard or weak understanding or confused about the aim of competition. There is no practical action to promote or implement it from localized government. This is a huge problem for regions o utside metropolitan area. It is important to courage and regenerate area through central authoritys support on centralized or decentralized planning. Global cities Global cities can be seen as competitive cities, which relate to different dimensions in economics, political, informative, cultural, societal, services concepts (Teece, 1990). The overall of global cities index in top 25 is assumption of business activity, human capital, information exchange, cultural experience and political engagement. The first bar chart below (Figure 1.1) displays that global elites are London, New York, and Paris which are hub of cultures, politics and economics with strong business activity and performance of labour, creativity (human capital). The top three have massive gap from last three in the ranking, in terms of strong business activities and performance of labour. Surprisingly, San Francisco and Boston take place in top 5 of good performance of city (Figure 1.2) based on personal well- being, economics, innovation, and governance. Nevertheless, it stands out from other cities may due to endeavour and implementation on innovation. Conversely, Houston instead of Paris or Tokyo squeezes into top 5; four out of five are cities from America, which can be presumed that America has advantageous position on economic and innovation in the world. These two bar charts prove that economic and innovation are the main reasons for city to be global city or competitive city. Figure 1.1 The Top 25 Global Cities Index, Rank and Score Source: A.T. Kearney, 2016 citied in Peterson, 2016, p2. Figure 1.2 The Top 25 Global Cities Outlook, Rank and Score Source: A.T. Kearney, 2016 citied in Peterson, 2016, p2. Evolving challenges Being ranked as a global city can be seen as a city with well competitiveness in environmental, political, spatial, social sites in order to further widen development. The competitive advantages have enormous influence on social welfare, politics position, public infrastructures, local services, financial support, media service, tourism planning, educational support and organization, international trading and may easily become headquarter of company or investment (Han 2005). Nevertheless, some issues and challenges have emerged, such as, new economy, technological changes, demographic density, urban design, and uncertainty (Ratcliffe, 2006). Globalization forces to transfer into new global economy, which may make different trends of competitiveness, politics, welfare, environment, investment and connectivity with others. To carter to sustain competitiveness, policies should be modified. Sometimes, planning policies hardly identify trends or require long-term periods to adapt it. While technological changes, informational functions are affected and implement of communication within cities and regions, progress equipment may influence progress and service. If city doesnt follow up technological changes, probably, it would lose competitive advantage in new era. Inflow of migrants is phenomenon of competitive city, extension of population strongly impacts on urban planning, affordable housing, work opportunities, criminal issues, transportation, greenfield, environmental problems, public infrastructures, education, and quality of life. Urban design and planning in competitive city consider about aesthetics objects, environme ntal dimension, political pressure, economic constraints, residential conditions. Approaches of planning are complex and uncertain, they suppose to adapt into dynamic changes, which means they should be creative and innovative strategies to prepare future changes. Evolving challenges from competition between cities and regions- Globalization is happening, transnational capital and international flows of labours are strongly influenced by it. Conclusion The competition between cities and regions do happen, meanwhile, so do cooperation. Both of them are crucial for cities to be global city. Many evidences demonstrate that cities and regions engage with competitiveness and cooperation (Tosic, 2007; Teece, 1990). The department of trade and industry of UK has published a report (2005) about the position in EU, and it clearly asserts that they do support the competition and open market in Europe in order to attract more creative people and investment, and reinforce on innovation and competition. The competition could encourage cities or regions have new ideas, moving forward, becoming different and better. There are more advantages than disadvantages in cities and regions competition, which brings diversity and implementation. If there is no competition between cities and regions, people dont want to move on, no motivation to improve or change themselves, and no city growth. Less opportunities for city, outflow of population, city will face recession. No one want to get better, city wont be better and wont catch the changing world and eventually, be deserted by the world.ÂÂ   With competitiveness, cities have proven more successful in long term. However, competition and cooperation are acting simultaneously, both are crucial for city growth, it is important to find the balance of them. The solution for evolving challenges may be decentralized in urban area. Localized authority should widen the concentration from centre, regenerating field, identifying role of authorities, following trends of globalization, cooperating with cities, more acquisition of knowledge from others. References Anonymous, 2001. UK Government: Fifteen cities compete for grant of a lord mayoralty. Press release, 25 October 2001. 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Effects of Exercise on the Human Body

Effects of Exercise on the Human Body Exercise represents one the highest levels of extreme stresses to which the body can be exposed. Exercise physiology is the study of the function of the human body during various acute and chronic exercise conditions. These effects are significant during both short, high intensity exercise as well as with prolonged strenuous exercise such as done in endurance sports like marathons, ultramarathons, and road bicycle racing. In exercise, the liver generates extra glucose, while increased cardiovascular activity by the heart, and respiration by the lungs, provides an increased supply of oxygen. When exercise is very prolonged and strenuous, a decline, however, can occur in blood levels of glucose. In some individuals, this might even cause hypoglycemia and hypoxemia. There can also be cognitive and physical impairments due to dehydration. Another risk is low plasma sodium blood levels. Prolonged exercise is made possible by the human thermoregulation capacity to remove exercise waste hea t by sweat evaporation. This capacity evolved to enable early humans after many hours of persistence hunting to exhaust game animals that cannot remove so effectively exercise heat from their body. In general, the exercise-related measurements established for women follow the same general principles as those established for men, except for the quantitative differences caused by differences in body size, body composition, and levels of testosterone. In women, the values of muscle strength, pulmonary ventilation, and cardiac output (all variables related with muscle mass) are generally 60-75% of the exercise physiology values recorded in men. When measured in terms of strength per square centimeter, the female muscle can achieve the same force of contraction as that of a male. The functions of muscle tissues assume roles in homeostasis, as follows: Excitability Property of receiving and responding to stimuli such as the following: Neurotransmitters: Acetylcholine (ACh) stimulates skeletal muscle to contract, electrical stimuli: Applying electrical stimuli between cardiac and smooth muscle cells causes the muscles to contract, Applying a shock to skeletal muscle causes contraction, Hormonal stimuli: Oxytocin stimulates smooth muscle in the uterus to contract during labor.Contractility Ability to shorten. Extensibility Ability to stretch without damageElasticity Ability to return to original shape after extensionThrough contraction, muscle provides motion of the body (skeletal muscle), motion of blood (cardiac muscle), and motion of hollow organs such as the uterus, esophagus, stomach, intestines, and bladder (smooth muscle).Muscle tissue also helps maintain posture and produce heat. A large amount of body heat is produced by metabolism and by muscle con traction. Muscle contraction during shivering warms the body. Skeletal muscle consists of fibers (cells). These cells are up to 100 Â µm in diameter and often are as long as the muscle. Each contains sarcoplasm (cytoplasm) and multiple peripheral nuclei per fiber. Skeletal muscle is actually formed by the fusion of hundreds of embryonic cells. Other cell structures include the following:Each fiber is covered by a sarcolemma (plasma membrane). The sarcoplasmic reticulum (smooth endoplasmic reticulum) stores calcium, which is released into the sarcoplasm during muscle contraction. Transverse tubules (T tubules), which are extensions of the sarcolemma that penetrate cells, transmit electrical impulses from the sarcolemma inward, so electrical impulses penetrate deeply into the cell. Besides conducting electricity along their walls, T tubules contain extracellular fluid rich in glucose and oxygen.The sarcoplasm of fiber is rich in glycogen (glucose polymer) granules and myoglobin (oxygen-storing protein). It also is rich in mitochondria. Each fibe r contains hundreds to thousands of rodlike myofibrils, which are bundles of thin and thick protein chains termed myofilaments. From a cross-sectional view of a myofibril, each thick filament is surrounded by a hexagonal array of 6 thin filaments. Each thin filament is surrounded by a triangular array of thick filaments.myofilaments are composed of 3 proteins: actin, tropomyosin, and troponin. Thick myofilaments consist of bundles of approximately 200 myosin molecules. Myosin molecules look like double-headed golf clubs (both heads at the same end). The heads of the golf clubs are called myosin heads; they are also called cross-bridges because they link thick and thin filaments during contraction. They contain actin andadenosine triphosphate (ATP) binding sites. Myosin heads project out from the thick filaments, allowing them to bind to the thin filaments during contraction. Actin is a long chain of multiple globular proteins, similar in shape to kidney beans. Each globular subunit contains a myosin-binding site. Tropomyosin is a long strand of protein that covers the myosin-binding sites on actin when the muscle is relaxed. Troponin is a polypeptide complex that binds to tropomyosin, helping to position it over the myosin-binding sites on actin. During muscle contraction, calcium binds troponin, which causes tropomyosin to roll off of the myosin binding sites on actin. A muscle action potential travels over sarcolemma and enters the T tubules, causing the sarcoplasmic reticulum to release calcium into the sarcoplasm. This triggers the contractile process.Myosin cross-bridges pull on the actin myofilaments, causing the thin myofilaments of a sarcomere to slide toward the centers of the H zones.Deep fascia is a broad band of dense irregular connective tissue beneath and around muscle and organs. Deep fascia is different from superficial fascia, which is loose areolar connective tissue.Other connective-tissue components (all are extensions of deep fascia) include epimysium, which covers the entire muscle; perimysium, which penetrates into muscle and surrounds bundles of fibers called fascicles; and endomysium, which is delicate, barely visible, loose areolar tissue covering individual fibers (ie, individual cells).Tendons and aponeuroses are tough extensions of epimysium, perimysium, and endomysium. Tendons and aponeuroses are made of dense regular co nnective tissue and attach the muscle to bone or other muscle. Aponeuroses are broad, flat tendons. Tendon sheaths contain synovial fluid and enclose certain tendons. Tendon sheaths allow tendons to slide back and forth next to each other with lower friction. Tenosynovitis is inflammation of the tendon sheaths and tendons, especially those of the wrists, shoulders, and elbows. Tendons are not contractile and not very stretchy; furthermore, they are not very vascular and they heal poorly. Nerves convey impulses for muscular contraction. Nerves are bundles of nerve cell processes. Each nerve cell process (ie, axon) divides at its tip into a few to 10,000 branches called telodendria. At the end of each of these branches is an axon terminal that is rich in neurotransmitters.Blood provides nutrients and oxygen for contraction. An artery and a vein usually accompany a nerve that penetrates skeletal muscle. Arteries in muscles dilate during active muscular activity, thus increasing the supply of oxygen and glucose.A motor nerve is a bundle of axons that conducts nerve impulses away from the brain or spinal cord toward muscles. Each axon transmits an action potential (ie, nerve impulse), which is a burst of electricity. The nerve impulse travels along the axons at a steady rate, like fire travels along a fuse; however, nerve impulses travel extremely fast. Each axon has 4-2000 or more branches (ie, telodendria), with an average of 150 telodendria. Each separate branch suppli es a separate muscle cell. Thus, if an axon has 10 branches, it supplies 10 muscle fibers. Small motor units are for fine control of muscles; large motor units are for muscles that do not require such fine control.The neuromuscular junction is made of an axon terminal and the portion of the muscle fiber sarcolemma it nearly touches (called the motor endplate). The neurotransmitter released at the neuromuscular junction in skeletal muscle is ACh. The motor endplate is rich in thousands of ACh receptors; the receptors are integral proteins containing binding sites for ACh and sodium channels. Nerve impulse (action potential) reaches the axon terminal, which triggers calcium influx into the axon terminal.Calcium influx causes synaptic vesicles to release ACh via exocytosis. ACh diffuses across synaptic cleft.ACh binds to theACh receptor on the sarcolemma. Succinylcholine, a drug used to induce paralysis during surgery, binds to ACh receptors more tightly than ACh. Succinylcholine initially causes some depolarization, but then itbinds to the receptor, preventing ACh from binding. Therefore, it blocks the muscles stimulation by ACh, causing paralysis. Another drug that acts in a similar fashion is curare. These drugs do not cause pain relief or unconsciousness; thus, they are combined with other drugs during surgery. When ACh binds the receptor, it opens chemically regulated ion channels, which are sodium channels through the receptor molecule. Sodium, which is in high concentration outside cells and in low concentration inside cells, rushes into the cell through the channels.The cell, whose resting membrane potential along the inside of the membrane is negative when comparedwith the outside of the membrane, becomes positively charged along the inside of the membrane when sodium (a positive ion) rushes in. This change from a negative charge to a positive charge along the inner membrane is termed depolarization. The depolarization of one region of the sarcolemma (the motor endplate) initiates an action potential, which is a propagating wave of depolarization that travels (propagates) along the sarcolemma. Regions of membrane that become depolarized rapidly restore their proper ionic concentrations along their inner and outer surfaces in a process termed repolarization. (This process of depolarization, propagation, and repolarization is similar to dominoes that topple each other but also spring back into the upright position shortly afterward.)The action potential also propagates along the membrane lining the T tubules entering the cell. This action potential traveling along the T tubules causes the sarcoplasmic reticulum to release calcium into sarcoplasm.Calcium binds with troponin, causing it to pull on tropomyosin to change its or ientation, exposing myosin-binding sites on actin. An ATPase, which also functions as a myosin cross-bridging protein, splits ATP into adenosine diphosphate (ADP) + phosphate (P) in the previous contraction cycle. This energizes the myosin head. The energized myosin head, or cross-bridge, combines with myosin-binding sites on actin. Power stroke occurs. The attachment of the energized cross-bridge triggers a pivoting motion (ie, power stroke) of the myosin head. During the power stroke, ADP and P are released from the myosin cross-bridge. The power stroke causes thin actinmyofilaments to slide past thick myosin myofilaments toward the center of the A bands.ATP attaches to the myosin head again, allowing it to detach from actin. (In rigor mortis, an ATP deficiency occurs. Cross-bridges remain, and the muscles are rigid.)ATP is broken down to ADP and P, which cocks the myosin head again, preparing it to perform another power stroke if needed. Repeated detachment and reattachment of the cross-bridges results in shortening without much increase in tension during the shortening phase (isotonic contraction) or results in increased tension without shortening (isometric contraction).Release of the enzyme acetylcholinesterasein the neuromuscular junction destroys ACh and stops the generation of a muscle action potential. Calcium is taken back up (resequestered) in the sarcoplasmic reticulum, and myosin cross-bridges separate. ATP is required to separate myosin-actin cross-bridges. The muscle fiber resumes its resting state. The chemical energy that fuels muscular activities is ATP. For the first 5 or 6 seconds of muscle power, muscular activity can depend on the ATP that is already present in the muscle cells. Beyond this time, new amounts of ATP must be formed to enable the activation of muscular contractions that are needed to support longer and more vigorous physical activities. For activities that require a quick burst of energy that cannot be supplied by the ATP present in the muscle cells, the next 10-15 seconds of muscle power can be provided through the bodys use of the phosphagen system, which uses a substance called creatine phosphate to recycle ADP into ATP.4 For longer and more intense periods of physical activity, the body must rely on systems that break down the sugars (glucose) to produce ATP. The complete breakdown of glucose occurs in 2 ways: through anaerobic respiration (does not use oxygen) and through aerobic respiration (occurs in the presence of oxygen). The anaerobic use of gluco se to form ATP occurs as the body increases its muscle use beyond the capability of the phosphagen system to supply energy. In particular, the glycogen lactic acid system, through its anaerobic breakdown of glucose, provides approximately 30-40 seconds more of maximal muscle activity. For this system, each glucose molecule is split into 2 pyruvic acid molecules, and energy is released to form several ATP molecules, providing the extra energy. Then, the pyruvic acid partially breaks down further to produce lactic acid. If the lactic acid is allowed to accumulate in the muscle, one experiences muscle fatigue. At this point, the aerobic system must activate.The aerobic system in the body is used for sports that require an extensive and enduring expenditure of energy, such as a marathon race. Endurance sports absolutely require aerobic energy. A large amount of ATP must be provided to muscles to sustain the muscle power needed to perform such events without an excessive production of la ctic acid. This can only be accomplished when oxygen in the body is used to break down the pyruvic acid (that was produced anaerobically) into carbon dioxide, water, and energy by way of a very complex series of reactions known as the citric acid cycle. This cycle supports muscle usage for as long as the nutrients in the body last. The breakdown of pyruvic acid requires oxygen and slows or eliminates the accumulation of lactic acid. In summary, the 3 different muscle metabolic systems that supply the energy required for various activities are as follows: Phosphagen system (for 10- to 15-sec bursts of energy)Glycogen lactic acid system (for another 30-40 sec of energy)Aerobic system (provides a great deal of energy that is only limited by the bodys ability to supply oxygen and other important nutrients) Many sports require the use of a combination of these metabolic systems. By considering the vigor of a sports activity and its duration, one can estimate very closely which of the ene rgy systems are used for each activity. During muscular exercise, blood vessels in muscles dilate and blood flow is increased in order to increase the available oxygen supply. Up to a point, the available oxygen is sufficient to meet the energy needs of the body. However, when muscular exertion is very great, oxygen cannot be supplied to muscle fibers fast enough, and the aerobic breakdown of pyruvic acid cannot produce all the ATP required for further muscle contraction. During such periods, additional ATP is generated by anaerobic glycolysis. In the process, most of the pyruvic acid produced is converted to lactic acid. Although approximately 80% of the lactic acid diffuses from the skeletal muscles and is transported to the liver for conversion back to glucose or glycogen, some lactic acid accumulates in muscle tissue, making muscle contraction painful and causing fatigue. Ultimately, once adequate oxygen is available, lactic acid must be catabolized completely into carbon dioxide and water. After exercise has stopped, extra oxygen is required to metabolize lactic acid; to replenish ATP, phosphocreatine, and glycogen; and to replace (pay back) any oxygen that has been borrowed from hemoglobin, myoglobin (an iron-containing substance similar to hemoglobin that is found in muscle fibers), air in the lungs, and body fluids. The additional oxygen that must be taken into the body after vigorous exercise to restore all systems to their normal states is called oxygen debt. The debt is paid back by labored breathing that continues after exercise has stopped. Thus, the accumulation of lactic acid causes hard breathing and sufficient discomfort to stop muscle activity until homeostasis is restored.5 Eventually, muscle glycogen must also be restored. Restoration of muscle glycogen is accomplished through diet and may take several days, depending on the intensity of exercise. The maximum rate of oxygen consumption during the aerobic catabolism of pyruvic acid is called maximal oxygen uptake. Maximal oxygen uptake is determined by sex (higher in males), age (highest at approximately age 20 y), and size (increases with body size). Highly trained athletes can have maximal oxygen uptakes that are twice that of average people, probably owing to a combination of genetics and training. As a result, highly trained athletes are capable of greater muscular activity without increasing their lactic acid production and have lower oxygen debts, which is why they do not become short of breath as readily as untrained individuals. The best examples of light exercise are walking and light jogging. The muscles that are recruited during this type of exercise are those that contain a large amount of type I muscle cells, and, because these cells have a good blood supply, it is easy for fuels and oxygen to travel to the muscle. ATP consumption makes ADP available for new ATP synthesis. The presence of ADP (and the resulting synthesis of ATP) simulates the movement of hydrogen (H+) into the mitochondria; this, in turn, reduces the proton gradient and thus stimulates electron transport. The hydrogen on the reduced form of nicotinamide adenine dinucleotide (NADH) is used up, nicotinamide adenine dinucleotide (NAD) becomes available, and fatty acids and glucose are oxidized. Incidentally, the calcium released during contraction stimulates the enzymes in the Krebs cycle and stimulates the movement of the glucose transporter 4 (GLUT-4) from inside of the muscle cell to the cell membrane. Both these exercise-induced respon ses augment the elevation in fuel oxidation caused by the increase in ATP consumption. An increase in the pace of running simply results in an increased rate of fuel consumption, an increased fatty acid release, and, therefore, an increase in the rate of muscle fatty acid oxidation. However, if the intensity of the exercise increases even further, a stage is reached in which the rate of fatty acid oxidation becomes limited. The reasons why the rate of fatty acid oxidation reaches a maximum are not clear, but it is possible that the enzymes in the beta-oxidation pathway are saturated (ie, they reach a stage in which their maximal velocity [Vmax] is less than the rate of acetyl-coenzyme A [acetyl-CoA] consumption in the Krebs cycle). Alternatively, it may be that the availability of carnitine (the chemical required to transport the fatty acids into the mitochondria) becomes limited. Whatever the reason, the consequence is that as the pace rises, the demand for acetyl-CoA cannot be met by fatty acid oxidation alone. The accumulation of acetyl-CoA that was so effective at inhibiting the oxidation of glucose is no longer present, so pyruvate dehydrogenase starts working again and pyruvate is converted into acetyl-CoA. In other words, more of the glucose that enters the muscle cell is oxidized fully to carbon dioxide. Therefore, the energy used during moderate exercise is derived from a mixture of fatty acid and glucose oxidation. As the intensity of the exercise increases even further (ie, running at the pace of middle-distance races), the rate at which the muscles can extract glucose from the blood becomes limited. In other words, the rate of glucose transport reaches Vmax, either because the blood cannot supply the glucose fast enough or the number of GLUT-4s becomes limited. ATP generation cannot be serviced completely by exogenous fuels, and ATP levels decrease. Not only does this stimulate phosphofructokinase, it also stimulates glycogen phosphorylase. This me ans that glycogen stored within the muscle cells is broken down to provide glucose. Therefore, the fuel mix during strenuous exercise is composed of contributions from blood-borne glucose and fatty acids and from endogenously stored glycogen.Being fit (biochemically speaking) means that the individual has a well-developed cardiovascular system that can efficiently supply nutrients and oxygen to the muscles. Fit people have muscle cells that are well perfused with capillaries (ie, they have a good muscle blood supply). Their muscle cells also have a large number of mitochondria, and those mitochondria have a high activity of Krebs cycle enzymes, electron transport carriers, and oxidation enzymes. Individuals who are unfit must endure the consequences of a poorer blood supply, fewer mitochondria, less electron transport units, a lower activity of the Krebs cycle, and poorer activity of beta-oxidation enzymes. To generate ATP in the mitochondria, a steady supply of fuel and oxygen and decent activity of the oxidizing enzymes and carriers are needed. If any of these components are lacking, the rate at which ATP can be produced by mitochondria is compromised. Under these circumstances, the production of ATP by aerobic means is not sufficient to provide the muscles with sufficient ATP to sustain contractions. The result is anaerobic ATP generation using glycolysis. Increasing the flux through glycolysis but not increasing the oxidative consumption of the resulting pyruvate increases the production of lactate. The purpose of respiration is to provide oxygen to the tissues and to remove carbon dioxide from the tissues. To accomplish this, 4 major events must be regulated, as follows: Pulmonary ventilation. Diffusion of oxygen and carbon dioxide between the alveoli and the blood, Transport of oxygen and carbon dioxide in the blood and body fluids and to and from the cells, Regulation of ventilation and other aspects of respiration: Exercise causes these factors to change, but the body is designed to maintain homeostasisWhen one goes from a state of rest to a state of maximal intensity of exercise, oxygen consumption, carbon dioxide formation, and total pulmonary and alveolar ventilation increase by approximately 20-fold. A linear relationship exists between oxygen consumption and ventilation. At maximal exercise, pulmonary ventilation is 100-110 L/min, whereas maximal breathing capacity is 150-170 L/min. Thus, the maximal breathing capacity is approximately 50% greater than the actual pulmon ary ventilation during maximal exercise. This extra ventilation provides an element of safety that can be called on if the situation demands it (eg, at high altitudes, under hot conditions, abnormality in the respiratory system). Therefore, the respiratory system itself is not usually the most limiting factor in the delivery of oxygen to the muscles during maximal muscle aerobic metabolism. VO2 max is the rate of oxygen consumption under maximal aerobic metabolism. This rate in short-term studies is found to increase only 10% with the effect of training. However, that of a person who runs in marathons is 45% greater than that of an untrained person. This is believed to be partly genetically determined (eg, stronger respiratory muscles, larger chest size in relation to body size) and partly due to long-term training. Oxygen diffusing capacity is a measure of the rate at which oxygen can diffuse from the alveoli into the blood. An increase in diffusing capacity is observed in a state of maximal exercise. This results from the fact that blood flow through many of the pulmonary capillaries is sluggish in the resting state. In exercise, increased blood flow through the lungs causes all of the pulmonary capillaries to be perfused at their maximal level, providing a greater surface area through which oxygen can diffuse into the pulmonary capillary blood. Athletes who require greater amounts of oxygen per minute have been found to have higher diffusing capacities, but the exact reason why is not yet known. Although one would expect the oxygen pressure of arterial blood to decrease during strenuous exercise and carbon dioxide pressure of venous blood to increase far above normal, this is not the case. Both of these values remain close to normal. Stimulatory impulses from higher centers of the brain and from joint and muscle proprioceptive stimulatory reflexes account for the nervous stimulation of the respiratory and vasomotor center that provides almost exactly the pr oper increase in pulmonary ventilation to keep the blood respiratory gases almost normal. If nervous signals are too strong or weak, chemical factors bring about the final adjustment in respiration that is required to maintain homeostasis. Regular exercise makes the cardiovascular system more efficient at pumping blood and delivering oxygen to the exercise muscles. Releases of adrenaline and lactic acid into the blood result in an increase of the heart rate (HR). Basic definitions of terms are as follows:VO2 equals cardiac output times oxygen uptake necessary to supply oxygen to muscles. The Fick equation is the basis for determination of VO2. Exercises increase some of the different components of the cardiovascular system, such as stroke volume (SV), cardiac output, systolic blood pressure (BP), and mean arterial pressure. A greater percentage of the cardiac output goes to the exercising muscles. At rest, muscles receive approximately 20% of the total blood flow, but during exercise, the blood flow to muscles increases to 80-85%. To meet the metabolic demands of skeletal muscle during exercise, 2 major adjustments to blood flow must occur. First, cardiac output from the heart must increase. Second, blood flow from ina ctive organs and tissues must be redistributed to active skeletal muscle. Generally, the longer the duration of exercise, the greater the role the cardiovascular system plays in metabolism and performance during the exercise bout. An example would be the 100-meter sprint (little or no cardiovascular involvement) versus a marathon (maximal cardiovascular involvement). The cardiovascular system helps transport oxygen and nutrients to tissues, transport carbon dioxide and other metabolites to the lungs and kidneys, and distribute hormones throughout the body. The cardiovascular system also assists with thermoregulation.The pumping of blood by the heart requires the following 2 mechanisms to be efficient:Alternate periods of relaxation and contraction of the atria and ventriclesCoordinated opening and closing of the heart valves for unidirectional flow of blood The cardiac cycle is divided into 2 phases: ventricular diastole and ventricular systole.This phase begins with the opening of the atrioventricular (AV) valves. The mitral valve (located between the left atrium and left ventricle) opens when the left ventricular pressure falls below the left atrial pressure, and the blood from left atrium enters the left ventricle.Later, as the blood continues to flow into the left ventricle, the pressure in both chambers tends to equalize.At the end of the di astole, left atrial contractions cause an increase in left atrial pressure, thus again creating a pressure gradient between the left atrium and ventricle and forcing blood into the left ventricle.Ventricular systole begins with the contraction of the left ventricle, which is caused by the spread of an action potential over the left ventricle. The contraction of the left ventricle causes an increase in the left ventricular pressure. When this pressure is higher than the left atrial pressure, the mitral valve is closed abruptly.The left ventricular pressure continues to rise after the mitral valve is closed. When the left ventricular pressure rises above the pressure in the aorta, the aortic valve opens. This period between the closure of the mitral valve and the opening of the aortic valve is called isovolumetric contraction phase.The blood ejects out of the left ventricle and into the aorta once the aortic valve is opened. As the left ventricular contraction is continued, 2 processe s lead to a fall in the left ventricular pressure. These include a decrease in the strength of the ventricular contraction and a decrease in the volume of blood in the ventricle.When the left ventricular pressure falls below the aortic pressure, the aortic valve is closed. After the closure of the aortic valve, the left ventricular pressure falls rapidly as the left ventricle relaxes. When this pressure falls below the left atrial pressure, the mitral valve opens and allows blood to enter left ventricle. The period between the closure of the aortic valve closure and the opening of the mitral valve is called isovolumetric relaxation time. Right-sided heart chambers undergo the same phases simultaneously. Most of the work of the heart is completed when ventricular pressure exists. The greater the ventricular pressure, the greater the workload of the heart. Increases in BP dramatically increase the workload of the heart, and this is why hypertension is so harmful to the heart.Arterial BP is the pressure that is exerted against the walls of the vascular system. BP is determined by cardiac output and peripheral resistance. Arterial pressure can be estimated using a sphygmomanometer and a stethoscope. The reference range for males is 120/80 mm Hg; the reference range for females is 110/70 mm Hg. The difference between systolic and diastolic pressure is called the pulse pressure. The average pressure during a cardiac cycle is called the mean arterial pressure (MAP). MAP determines the rate of blood flow through the systemic circulation.During rest, MAP = diastolic BP + (0.33 X pulse pressure). For example, MAP = 80 + (0.33 X [120-80]), MAP = 93 mm Hg. During exercise, MAP = diastolic BP + (0.50 X pulse pressure). For example, MAP = 80 + (0.50 X [160-80]), MAP = 120 mm Hg. The heart has the ability to generate its own electrical activity, which is known as intrinsic rhythm. In the healthy heart, contraction is initiated in the sinoatrial (SA) node, which is often called the hearts pacemaker. If the SA node cannot set the rate, then other tissues in the heart are able to generate an electrical potential and establish the HR.The parasympathetic nervous system and the sympathetic nervous system affect a personsHR. Parasympathetic nervous system: The vagus nerve originates in the medulla and innervates the SA and AV nodes. The nerve releases ACh as the neurotransmitter. The response is a decrease in SA node and AV node activity, which causes a decrease in HR. Sympathetic nervous system: The nerves arise from the spinal cord and innervate the SA node and ventricular muscle mass. The nerves release norepinephrine as the neurotransmitter. The response is an increase in HR and a force of contraction of the ventricles.At rest, sympathetic and parasympathetic ne rvous stimulation are in balance. During exercise, parasympathetic stimulation decreases and sympathetic stimulation increases. Several factors can alter sympathetic nervous system input.Baroreceptors are groups of neurons located in the carotid arteries, the arch of aorta, and the right atrium. These neurons sense changes in pressure in the vascular system. An increase in BP results in an increase in parasympathetic activity except during exercise, when the sympathetic activity overrides the parasympathetic activity. Chemoreceptors are groups of neurons located in the arch of the aorta and the carotid arteries. These neurons sense changes in oxygen concentration. When oxygen concentration in the blood is decreased, parasympathetic activity decreasesand sympathetic activity increases. Temperature receptors are neurons located throughout the body. These neurons are sensitive to changes in body temperature. As temperature increases, sympathetic activity increases to cool Effects of Exercise on the Human Body Effects of Exercise on the Human Body Exercise represents one the highest levels of extreme stresses to which the body can be exposed. Exercise physiology is the study of the function of the human body during various acute and chronic exercise conditions. These effects are significant during both short, high intensity exercise as well as with prolonged strenuous exercise such as done in endurance sports like marathons, ultramarathons, and road bicycle racing. In exercise, the liver generates extra glucose, while increased cardiovascular activity by the heart, and respiration by the lungs, provides an increased supply of oxygen. When exercise is very prolonged and strenuous, a decline, however, can occur in blood levels of glucose. In some individuals, this might even cause hypoglycemia and hypoxemia. There can also be cognitive and physical impairments due to dehydration. Another risk is low plasma sodium blood levels. Prolonged exercise is made possible by the human thermoregulation capacity to remove exercise waste hea t by sweat evaporation. This capacity evolved to enable early humans after many hours of persistence hunting to exhaust game animals that cannot remove so effectively exercise heat from their body. In general, the exercise-related measurements established for women follow the same general principles as those established for men, except for the quantitative differences caused by differences in body size, body composition, and levels of testosterone. In women, the values of muscle strength, pulmonary ventilation, and cardiac output (all variables related with muscle mass) are generally 60-75% of the exercise physiology values recorded in men. When measured in terms of strength per square centimeter, the female muscle can achieve the same force of contraction as that of a male. The functions of muscle tissues assume roles in homeostasis, as follows: Excitability Property of receiving and responding to stimuli such as the following: Neurotransmitters: Acetylcholine (ACh) stimulates skeletal muscle to contract, electrical stimuli: Applying electrical stimuli between cardiac and smooth muscle cells causes the muscles to contract, Applying a shock to skeletal muscle causes contraction, Hormonal stimuli: Oxytocin stimulates smooth muscle in the uterus to contract during labor.Contractility Ability to shorten. Extensibility Ability to stretch without damageElasticity Ability to return to original shape after extensionThrough contraction, muscle provides motion of the body (skeletal muscle), motion of blood (cardiac muscle), and motion of hollow organs such as the uterus, esophagus, stomach, intestines, and bladder (smooth muscle).Muscle tissue also helps maintain posture and produce heat. A large amount of body heat is produced by metabolism and by muscle con traction. Muscle contraction during shivering warms the body. Skeletal muscle consists of fibers (cells). These cells are up to 100 Â µm in diameter and often are as long as the muscle. Each contains sarcoplasm (cytoplasm) and multiple peripheral nuclei per fiber. Skeletal muscle is actually formed by the fusion of hundreds of embryonic cells. Other cell structures include the following:Each fiber is covered by a sarcolemma (plasma membrane). The sarcoplasmic reticulum (smooth endoplasmic reticulum) stores calcium, which is released into the sarcoplasm during muscle contraction. Transverse tubules (T tubules), which are extensions of the sarcolemma that penetrate cells, transmit electrical impulses from the sarcolemma inward, so electrical impulses penetrate deeply into the cell. Besides conducting electricity along their walls, T tubules contain extracellular fluid rich in glucose and oxygen.The sarcoplasm of fiber is rich in glycogen (glucose polymer) granules and myoglobin (oxygen-storing protein). It also is rich in mitochondria. Each fibe r contains hundreds to thousands of rodlike myofibrils, which are bundles of thin and thick protein chains termed myofilaments. From a cross-sectional view of a myofibril, each thick filament is surrounded by a hexagonal array of 6 thin filaments. Each thin filament is surrounded by a triangular array of thick filaments.myofilaments are composed of 3 proteins: actin, tropomyosin, and troponin. Thick myofilaments consist of bundles of approximately 200 myosin molecules. Myosin molecules look like double-headed golf clubs (both heads at the same end). The heads of the golf clubs are called myosin heads; they are also called cross-bridges because they link thick and thin filaments during contraction. They contain actin andadenosine triphosphate (ATP) binding sites. Myosin heads project out from the thick filaments, allowing them to bind to the thin filaments during contraction. Actin is a long chain of multiple globular proteins, similar in shape to kidney beans. Each globular subunit contains a myosin-binding site. Tropomyosin is a long strand of protein that covers the myosin-binding sites on actin when the muscle is relaxed. Troponin is a polypeptide complex that binds to tropomyosin, helping to position it over the myosin-binding sites on actin. During muscle contraction, calcium binds troponin, which causes tropomyosin to roll off of the myosin binding sites on actin. A muscle action potential travels over sarcolemma and enters the T tubules, causing the sarcoplasmic reticulum to release calcium into the sarcoplasm. This triggers the contractile process.Myosin cross-bridges pull on the actin myofilaments, causing the thin myofilaments of a sarcomere to slide toward the centers of the H zones.Deep fascia is a broad band of dense irregular connective tissue beneath and around muscle and organs. Deep fascia is different from superficial fascia, which is loose areolar connective tissue.Other connective-tissue components (all are extensions of deep fascia) include epimysium, which covers the entire muscle; perimysium, which penetrates into muscle and surrounds bundles of fibers called fascicles; and endomysium, which is delicate, barely visible, loose areolar tissue covering individual fibers (ie, individual cells).Tendons and aponeuroses are tough extensions of epimysium, perimysium, and endomysium. Tendons and aponeuroses are made of dense regular co nnective tissue and attach the muscle to bone or other muscle. Aponeuroses are broad, flat tendons. Tendon sheaths contain synovial fluid and enclose certain tendons. Tendon sheaths allow tendons to slide back and forth next to each other with lower friction. Tenosynovitis is inflammation of the tendon sheaths and tendons, especially those of the wrists, shoulders, and elbows. Tendons are not contractile and not very stretchy; furthermore, they are not very vascular and they heal poorly. Nerves convey impulses for muscular contraction. Nerves are bundles of nerve cell processes. Each nerve cell process (ie, axon) divides at its tip into a few to 10,000 branches called telodendria. At the end of each of these branches is an axon terminal that is rich in neurotransmitters.Blood provides nutrients and oxygen for contraction. An artery and a vein usually accompany a nerve that penetrates skeletal muscle. Arteries in muscles dilate during active muscular activity, thus increasing the supply of oxygen and glucose.A motor nerve is a bundle of axons that conducts nerve impulses away from the brain or spinal cord toward muscles. Each axon transmits an action potential (ie, nerve impulse), which is a burst of electricity. The nerve impulse travels along the axons at a steady rate, like fire travels along a fuse; however, nerve impulses travel extremely fast. Each axon has 4-2000 or more branches (ie, telodendria), with an average of 150 telodendria. Each separate branch suppli es a separate muscle cell. Thus, if an axon has 10 branches, it supplies 10 muscle fibers. Small motor units are for fine control of muscles; large motor units are for muscles that do not require such fine control.The neuromuscular junction is made of an axon terminal and the portion of the muscle fiber sarcolemma it nearly touches (called the motor endplate). The neurotransmitter released at the neuromuscular junction in skeletal muscle is ACh. The motor endplate is rich in thousands of ACh receptors; the receptors are integral proteins containing binding sites for ACh and sodium channels. Nerve impulse (action potential) reaches the axon terminal, which triggers calcium influx into the axon terminal.Calcium influx causes synaptic vesicles to release ACh via exocytosis. ACh diffuses across synaptic cleft.ACh binds to theACh receptor on the sarcolemma. Succinylcholine, a drug used to induce paralysis during surgery, binds to ACh receptors more tightly than ACh. Succinylcholine initially causes some depolarization, but then itbinds to the receptor, preventing ACh from binding. Therefore, it blocks the muscles stimulation by ACh, causing paralysis. Another drug that acts in a similar fashion is curare. These drugs do not cause pain relief or unconsciousness; thus, they are combined with other drugs during surgery. When ACh binds the receptor, it opens chemically regulated ion channels, which are sodium channels through the receptor molecule. Sodium, which is in high concentration outside cells and in low concentration inside cells, rushes into the cell through the channels.The cell, whose resting membrane potential along the inside of the membrane is negative when comparedwith the outside of the membrane, becomes positively charged along the inside of the membrane when sodium (a positive ion) rushes in. This change from a negative charge to a positive charge along the inner membrane is termed depolarization. The depolarization of one region of the sarcolemma (the motor endplate) initiates an action potential, which is a propagating wave of depolarization that travels (propagates) along the sarcolemma. Regions of membrane that become depolarized rapidly restore their proper ionic concentrations along their inner and outer surfaces in a process termed repolarization. (This process of depolarization, propagation, and repolarization is similar to dominoes that topple each other but also spring back into the upright position shortly afterward.)The action potential also propagates along the membrane lining the T tubules entering the cell. This action potential traveling along the T tubules causes the sarcoplasmic reticulum to release calcium into sarcoplasm.Calcium binds with troponin, causing it to pull on tropomyosin to change its or ientation, exposing myosin-binding sites on actin. An ATPase, which also functions as a myosin cross-bridging protein, splits ATP into adenosine diphosphate (ADP) + phosphate (P) in the previous contraction cycle. This energizes the myosin head. The energized myosin head, or cross-bridge, combines with myosin-binding sites on actin. Power stroke occurs. The attachment of the energized cross-bridge triggers a pivoting motion (ie, power stroke) of the myosin head. During the power stroke, ADP and P are released from the myosin cross-bridge. The power stroke causes thin actinmyofilaments to slide past thick myosin myofilaments toward the center of the A bands.ATP attaches to the myosin head again, allowing it to detach from actin. (In rigor mortis, an ATP deficiency occurs. Cross-bridges remain, and the muscles are rigid.)ATP is broken down to ADP and P, which cocks the myosin head again, preparing it to perform another power stroke if needed. Repeated detachment and reattachment of the cross-bridges results in shortening without much increase in tension during the shortening phase (isotonic contraction) or results in increased tension without shortening (isometric contraction).Release of the enzyme acetylcholinesterasein the neuromuscular junction destroys ACh and stops the generation of a muscle action potential. Calcium is taken back up (resequestered) in the sarcoplasmic reticulum, and myosin cross-bridges separate. ATP is required to separate myosin-actin cross-bridges. The muscle fiber resumes its resting state. The chemical energy that fuels muscular activities is ATP. For the first 5 or 6 seconds of muscle power, muscular activity can depend on the ATP that is already present in the muscle cells. Beyond this time, new amounts of ATP must be formed to enable the activation of muscular contractions that are needed to support longer and more vigorous physical activities. For activities that require a quick burst of energy that cannot be supplied by the ATP present in the muscle cells, the next 10-15 seconds of muscle power can be provided through the bodys use of the phosphagen system, which uses a substance called creatine phosphate to recycle ADP into ATP.4 For longer and more intense periods of physical activity, the body must rely on systems that break down the sugars (glucose) to produce ATP. The complete breakdown of glucose occurs in 2 ways: through anaerobic respiration (does not use oxygen) and through aerobic respiration (occurs in the presence of oxygen). The anaerobic use of gluco se to form ATP occurs as the body increases its muscle use beyond the capability of the phosphagen system to supply energy. In particular, the glycogen lactic acid system, through its anaerobic breakdown of glucose, provides approximately 30-40 seconds more of maximal muscle activity. For this system, each glucose molecule is split into 2 pyruvic acid molecules, and energy is released to form several ATP molecules, providing the extra energy. Then, the pyruvic acid partially breaks down further to produce lactic acid. If the lactic acid is allowed to accumulate in the muscle, one experiences muscle fatigue. At this point, the aerobic system must activate.The aerobic system in the body is used for sports that require an extensive and enduring expenditure of energy, such as a marathon race. Endurance sports absolutely require aerobic energy. A large amount of ATP must be provided to muscles to sustain the muscle power needed to perform such events without an excessive production of la ctic acid. This can only be accomplished when oxygen in the body is used to break down the pyruvic acid (that was produced anaerobically) into carbon dioxide, water, and energy by way of a very complex series of reactions known as the citric acid cycle. This cycle supports muscle usage for as long as the nutrients in the body last. The breakdown of pyruvic acid requires oxygen and slows or eliminates the accumulation of lactic acid. In summary, the 3 different muscle metabolic systems that supply the energy required for various activities are as follows: Phosphagen system (for 10- to 15-sec bursts of energy)Glycogen lactic acid system (for another 30-40 sec of energy)Aerobic system (provides a great deal of energy that is only limited by the bodys ability to supply oxygen and other important nutrients) Many sports require the use of a combination of these metabolic systems. By considering the vigor of a sports activity and its duration, one can estimate very closely which of the ene rgy systems are used for each activity. During muscular exercise, blood vessels in muscles dilate and blood flow is increased in order to increase the available oxygen supply. Up to a point, the available oxygen is sufficient to meet the energy needs of the body. However, when muscular exertion is very great, oxygen cannot be supplied to muscle fibers fast enough, and the aerobic breakdown of pyruvic acid cannot produce all the ATP required for further muscle contraction. During such periods, additional ATP is generated by anaerobic glycolysis. In the process, most of the pyruvic acid produced is converted to lactic acid. Although approximately 80% of the lactic acid diffuses from the skeletal muscles and is transported to the liver for conversion back to glucose or glycogen, some lactic acid accumulates in muscle tissue, making muscle contraction painful and causing fatigue. Ultimately, once adequate oxygen is available, lactic acid must be catabolized completely into carbon dioxide and water. After exercise has stopped, extra oxygen is required to metabolize lactic acid; to replenish ATP, phosphocreatine, and glycogen; and to replace (pay back) any oxygen that has been borrowed from hemoglobin, myoglobin (an iron-containing substance similar to hemoglobin that is found in muscle fibers), air in the lungs, and body fluids. The additional oxygen that must be taken into the body after vigorous exercise to restore all systems to their normal states is called oxygen debt. The debt is paid back by labored breathing that continues after exercise has stopped. Thus, the accumulation of lactic acid causes hard breathing and sufficient discomfort to stop muscle activity until homeostasis is restored.5 Eventually, muscle glycogen must also be restored. Restoration of muscle glycogen is accomplished through diet and may take several days, depending on the intensity of exercise. The maximum rate of oxygen consumption during the aerobic catabolism of pyruvic acid is called maximal oxygen uptake. Maximal oxygen uptake is determined by sex (higher in males), age (highest at approximately age 20 y), and size (increases with body size). Highly trained athletes can have maximal oxygen uptakes that are twice that of average people, probably owing to a combination of genetics and training. As a result, highly trained athletes are capable of greater muscular activity without increasing their lactic acid production and have lower oxygen debts, which is why they do not become short of breath as readily as untrained individuals. The best examples of light exercise are walking and light jogging. The muscles that are recruited during this type of exercise are those that contain a large amount of type I muscle cells, and, because these cells have a good blood supply, it is easy for fuels and oxygen to travel to the muscle. ATP consumption makes ADP available for new ATP synthesis. The presence of ADP (and the resulting synthesis of ATP) simulates the movement of hydrogen (H+) into the mitochondria; this, in turn, reduces the proton gradient and thus stimulates electron transport. The hydrogen on the reduced form of nicotinamide adenine dinucleotide (NADH) is used up, nicotinamide adenine dinucleotide (NAD) becomes available, and fatty acids and glucose are oxidized. Incidentally, the calcium released during contraction stimulates the enzymes in the Krebs cycle and stimulates the movement of the glucose transporter 4 (GLUT-4) from inside of the muscle cell to the cell membrane. Both these exercise-induced respon ses augment the elevation in fuel oxidation caused by the increase in ATP consumption. An increase in the pace of running simply results in an increased rate of fuel consumption, an increased fatty acid release, and, therefore, an increase in the rate of muscle fatty acid oxidation. However, if the intensity of the exercise increases even further, a stage is reached in which the rate of fatty acid oxidation becomes limited. The reasons why the rate of fatty acid oxidation reaches a maximum are not clear, but it is possible that the enzymes in the beta-oxidation pathway are saturated (ie, they reach a stage in which their maximal velocity [Vmax] is less than the rate of acetyl-coenzyme A [acetyl-CoA] consumption in the Krebs cycle). Alternatively, it may be that the availability of carnitine (the chemical required to transport the fatty acids into the mitochondria) becomes limited. Whatever the reason, the consequence is that as the pace rises, the demand for acetyl-CoA cannot be met by fatty acid oxidation alone. The accumulation of acetyl-CoA that was so effective at inhibiting the oxidation of glucose is no longer present, so pyruvate dehydrogenase starts working again and pyruvate is converted into acetyl-CoA. In other words, more of the glucose that enters the muscle cell is oxidized fully to carbon dioxide. Therefore, the energy used during moderate exercise is derived from a mixture of fatty acid and glucose oxidation. As the intensity of the exercise increases even further (ie, running at the pace of middle-distance races), the rate at which the muscles can extract glucose from the blood becomes limited. In other words, the rate of glucose transport reaches Vmax, either because the blood cannot supply the glucose fast enough or the number of GLUT-4s becomes limited. ATP generation cannot be serviced completely by exogenous fuels, and ATP levels decrease. Not only does this stimulate phosphofructokinase, it also stimulates glycogen phosphorylase. This me ans that glycogen stored within the muscle cells is broken down to provide glucose. Therefore, the fuel mix during strenuous exercise is composed of contributions from blood-borne glucose and fatty acids and from endogenously stored glycogen.Being fit (biochemically speaking) means that the individual has a well-developed cardiovascular system that can efficiently supply nutrients and oxygen to the muscles. Fit people have muscle cells that are well perfused with capillaries (ie, they have a good muscle blood supply). Their muscle cells also have a large number of mitochondria, and those mitochondria have a high activity of Krebs cycle enzymes, electron transport carriers, and oxidation enzymes. Individuals who are unfit must endure the consequences of a poorer blood supply, fewer mitochondria, less electron transport units, a lower activity of the Krebs cycle, and poorer activity of beta-oxidation enzymes. To generate ATP in the mitochondria, a steady supply of fuel and oxygen and decent activity of the oxidizing enzymes and carriers are needed. If any of these components are lacking, the rate at which ATP can be produced by mitochondria is compromised. Under these circumstances, the production of ATP by aerobic means is not sufficient to provide the muscles with sufficient ATP to sustain contractions. The result is anaerobic ATP generation using glycolysis. Increasing the flux through glycolysis but not increasing the oxidative consumption of the resulting pyruvate increases the production of lactate. The purpose of respiration is to provide oxygen to the tissues and to remove carbon dioxide from the tissues. To accomplish this, 4 major events must be regulated, as follows: Pulmonary ventilation. Diffusion of oxygen and carbon dioxide between the alveoli and the blood, Transport of oxygen and carbon dioxide in the blood and body fluids and to and from the cells, Regulation of ventilation and other aspects of respiration: Exercise causes these factors to change, but the body is designed to maintain homeostasisWhen one goes from a state of rest to a state of maximal intensity of exercise, oxygen consumption, carbon dioxide formation, and total pulmonary and alveolar ventilation increase by approximately 20-fold. A linear relationship exists between oxygen consumption and ventilation. At maximal exercise, pulmonary ventilation is 100-110 L/min, whereas maximal breathing capacity is 150-170 L/min. Thus, the maximal breathing capacity is approximately 50% greater than the actual pulmon ary ventilation during maximal exercise. This extra ventilation provides an element of safety that can be called on if the situation demands it (eg, at high altitudes, under hot conditions, abnormality in the respiratory system). Therefore, the respiratory system itself is not usually the most limiting factor in the delivery of oxygen to the muscles during maximal muscle aerobic metabolism. VO2 max is the rate of oxygen consumption under maximal aerobic metabolism. This rate in short-term studies is found to increase only 10% with the effect of training. However, that of a person who runs in marathons is 45% greater than that of an untrained person. This is believed to be partly genetically determined (eg, stronger respiratory muscles, larger chest size in relation to body size) and partly due to long-term training. Oxygen diffusing capacity is a measure of the rate at which oxygen can diffuse from the alveoli into the blood. An increase in diffusing capacity is observed in a state of maximal exercise. This results from the fact that blood flow through many of the pulmonary capillaries is sluggish in the resting state. In exercise, increased blood flow through the lungs causes all of the pulmonary capillaries to be perfused at their maximal level, providing a greater surface area through which oxygen can diffuse into the pulmonary capillary blood. Athletes who require greater amounts of oxygen per minute have been found to have higher diffusing capacities, but the exact reason why is not yet known. Although one would expect the oxygen pressure of arterial blood to decrease during strenuous exercise and carbon dioxide pressure of venous blood to increase far above normal, this is not the case. Both of these values remain close to normal. Stimulatory impulses from higher centers of the brain and from joint and muscle proprioceptive stimulatory reflexes account for the nervous stimulation of the respiratory and vasomotor center that provides almost exactly the pr oper increase in pulmonary ventilation to keep the blood respiratory gases almost normal. If nervous signals are too strong or weak, chemical factors bring about the final adjustment in respiration that is required to maintain homeostasis. Regular exercise makes the cardiovascular system more efficient at pumping blood and delivering oxygen to the exercise muscles. Releases of adrenaline and lactic acid into the blood result in an increase of the heart rate (HR). Basic definitions of terms are as follows:VO2 equals cardiac output times oxygen uptake necessary to supply oxygen to muscles. The Fick equation is the basis for determination of VO2. Exercises increase some of the different components of the cardiovascular system, such as stroke volume (SV), cardiac output, systolic blood pressure (BP), and mean arterial pressure. A greater percentage of the cardiac output goes to the exercising muscles. At rest, muscles receive approximately 20% of the total blood flow, but during exercise, the blood flow to muscles increases to 80-85%. To meet the metabolic demands of skeletal muscle during exercise, 2 major adjustments to blood flow must occur. First, cardiac output from the heart must increase. Second, blood flow from ina ctive organs and tissues must be redistributed to active skeletal muscle. Generally, the longer the duration of exercise, the greater the role the cardiovascular system plays in metabolism and performance during the exercise bout. An example would be the 100-meter sprint (little or no cardiovascular involvement) versus a marathon (maximal cardiovascular involvement). The cardiovascular system helps transport oxygen and nutrients to tissues, transport carbon dioxide and other metabolites to the lungs and kidneys, and distribute hormones throughout the body. The cardiovascular system also assists with thermoregulation.The pumping of blood by the heart requires the following 2 mechanisms to be efficient:Alternate periods of relaxation and contraction of the atria and ventriclesCoordinated opening and closing of the heart valves for unidirectional flow of blood The cardiac cycle is divided into 2 phases: ventricular diastole and ventricular systole.This phase begins with the opening of the atrioventricular (AV) valves. The mitral valve (located between the left atrium and left ventricle) opens when the left ventricular pressure falls below the left atrial pressure, and the blood from left atrium enters the left ventricle.Later, as the blood continues to flow into the left ventricle, the pressure in both chambers tends to equalize.At the end of the di astole, left atrial contractions cause an increase in left atrial pressure, thus again creating a pressure gradient between the left atrium and ventricle and forcing blood into the left ventricle.Ventricular systole begins with the contraction of the left ventricle, which is caused by the spread of an action potential over the left ventricle. The contraction of the left ventricle causes an increase in the left ventricular pressure. When this pressure is higher than the left atrial pressure, the mitral valve is closed abruptly.The left ventricular pressure continues to rise after the mitral valve is closed. When the left ventricular pressure rises above the pressure in the aorta, the aortic valve opens. This period between the closure of the mitral valve and the opening of the aortic valve is called isovolumetric contraction phase.The blood ejects out of the left ventricle and into the aorta once the aortic valve is opened. As the left ventricular contraction is continued, 2 processe s lead to a fall in the left ventricular pressure. These include a decrease in the strength of the ventricular contraction and a decrease in the volume of blood in the ventricle.When the left ventricular pressure falls below the aortic pressure, the aortic valve is closed. After the closure of the aortic valve, the left ventricular pressure falls rapidly as the left ventricle relaxes. When this pressure falls below the left atrial pressure, the mitral valve opens and allows blood to enter left ventricle. The period between the closure of the aortic valve closure and the opening of the mitral valve is called isovolumetric relaxation time. Right-sided heart chambers undergo the same phases simultaneously. Most of the work of the heart is completed when ventricular pressure exists. The greater the ventricular pressure, the greater the workload of the heart. Increases in BP dramatically increase the workload of the heart, and this is why hypertension is so harmful to the heart.Arterial BP is the pressure that is exerted against the walls of the vascular system. BP is determined by cardiac output and peripheral resistance. Arterial pressure can be estimated using a sphygmomanometer and a stethoscope. The reference range for males is 120/80 mm Hg; the reference range for females is 110/70 mm Hg. The difference between systolic and diastolic pressure is called the pulse pressure. The average pressure during a cardiac cycle is called the mean arterial pressure (MAP). MAP determines the rate of blood flow through the systemic circulation.During rest, MAP = diastolic BP + (0.33 X pulse pressure). For example, MAP = 80 + (0.33 X [120-80]), MAP = 93 mm Hg. During exercise, MAP = diastolic BP + (0.50 X pulse pressure). For example, MAP = 80 + (0.50 X [160-80]), MAP = 120 mm Hg. The heart has the ability to generate its own electrical activity, which is known as intrinsic rhythm. In the healthy heart, contraction is initiated in the sinoatrial (SA) node, which is often called the hearts pacemaker. If the SA node cannot set the rate, then other tissues in the heart are able to generate an electrical potential and establish the HR.The parasympathetic nervous system and the sympathetic nervous system affect a personsHR. Parasympathetic nervous system: The vagus nerve originates in the medulla and innervates the SA and AV nodes. The nerve releases ACh as the neurotransmitter. The response is a decrease in SA node and AV node activity, which causes a decrease in HR. Sympathetic nervous system: The nerves arise from the spinal cord and innervate the SA node and ventricular muscle mass. The nerves release norepinephrine as the neurotransmitter. The response is an increase in HR and a force of contraction of the ventricles.At rest, sympathetic and parasympathetic ne rvous stimulation are in balance. During exercise, parasympathetic stimulation decreases and sympathetic stimulation increases. Several factors can alter sympathetic nervous system input.Baroreceptors are groups of neurons located in the carotid arteries, the arch of aorta, and the right atrium. These neurons sense changes in pressure in the vascular system. An increase in BP results in an increase in parasympathetic activity except during exercise, when the sympathetic activity overrides the parasympathetic activity. Chemoreceptors are groups of neurons located in the arch of the aorta and the carotid arteries. These neurons sense changes in oxygen concentration. When oxygen concentration in the blood is decreased, parasympathetic activity decreasesand sympathetic activity increases. Temperature receptors are neurons located throughout the body. These neurons are sensitive to changes in body temperature. As temperature increases, sympathetic activity increases to cool